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Panama from $423

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Cheap round-trip flights to Panama

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

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Flights to Panama starting at $423

Have you been telling yourself, “2025 is the year I travel more and sit less”? Well, here we are and there you are. So, where are you going? Looks like a flight to Panama is calling. Good thing we can help you bag that flight out of town for cheap, so you can get your resolutions resolved.

Travel like you mean it

When you land it’s not straight to the tourist traps for you. You have things to do and see in Panama that aren’t on a map or in the “Best of. . .” guides. You know this region is filled with hidden haunts, locals-only know favorites, and the off-beat-so-weird-it’s-amazing places. And you plan to find every last one of them. Good thing you’ll save a grip of cash on your flight so you can daytrip far and wide.

You won’t have to wing it

So how do you score that killer deal on a flight to Panama? Easy, go through us. These aren’t pie in the sky deals, but ones you can actually score. Filter flights to Panama by:

  • Hotwire Hot Rate: Do you have a flexible schedule? Hit up the Hotwire Hot Rate and land a super cheap flight to Panama. We’ll reveal the airline and exact time after you book.
  • Price: How low can we go? Find out. We have prices from $423 to $1,241.
  • Duration: Want to get to Panama as fast as you can? Or maybe you don’t mind taking your time to save a few bucks here and there.
  • Departure or Arrival: Like to arrive in the a.m. to get your day going? Or are you a night owl that knows the best fun happens late night? The choice is yours.

So are you going to live up to those travel plans or kick the can to next year? Book your flight to Panama today and get going.

Last Minute Hotel Deals in Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
The price is $138 per night from Apr 29 to Apr 30
$138
includes taxes & fees
Apr 29 - Apr 30
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (3,846 reviews)
"Very nice place"

Reviewed on Apr 17, 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
The price is $131 per night from Apr 21 to Apr 22
$131
includes taxes & fees
Apr 21 - Apr 22
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (2,101 reviews)
"Close to airport, good stay between flights, friendly and enough efficient staff."

Reviewed on Apr 16, 2025

Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
The price is $251 per night from May 17 to May 18
$251
includes taxes & fees
May 17 - May 18
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.4/10 Good! (1,001 reviews)
"I thought the customer service was great with all staff, and rooms were clean. Disappointed with the limited food option and the early closing hours of the pools and preferred lounge."

Reviewed on Apr 10, 2025

Dreams Playa Bonita Panama - All Inclusive
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Riande Urban Hotel

Riande Urban Hotel

3.5 out of 5
El Cangrejo; Calle Eusebio A, Morales, Panama City, Panama
The price is $72 per night from Apr 20 to Apr 21
$72
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and 2 restaurants. Our guests praise the bar and the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
"very nice hotel. I would like to stay again for sure."

Reviewed on Apr 14, 2025

Riande Urban Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.