Search for Cheap Deals on
4 Star Hotels in St. Charles

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured 4 Star St. Charles Hotels

Hyatt Regency St. Louis at The Arch
4 out of 5
Fully refundable
  • 36 min drive from Ameristar Casino St. Charles
The price is $149 per night from Jun 15 to Jun 16
$149
per night
Jun 15 - Jun 16
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min drive from Ameristar Casino St. Charles
The price is $122 per night from Jul 5 to Jul 6
$122
per night
Jul 5 - Jul 6
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Renaissance St. Louis Airport Hotel
21C Museum Hotel St Louis
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $161 per night from Jun 20 to Jun 21
$161
per night
Jun 20 - Jun 21
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions St. Louis Union Station and Enterprise ...
21C Museum Hotel St Louis
Save an average of 15% on thousands of hotels when you're signed in
Moonrise Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 25 min drive from Ameristar Casino St. Charles
The price is $155 per night from Jul 1 to Jul 2
$155
per night
Jul 1 - Jul 2
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the bar and the helpful staff in our reviews. ...
Moonrise Hotel
Le Méridien St. Louis Clayton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from Ameristar Casino St. Charles
The price is $179 per night from Jun 9 to Jun 10
$179
per night
Jun 9 - Jun 10
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Popular attractions St. Louis ...
Le Méridien St. Louis Clayton
Live by Loews - St.Louis
4 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from Ameristar Casino St. Charles
The price is $159 per night from Jul 1 to Jul 2
$159
per night
Jul 1 - Jul 2
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
Live by Loews - St.Louis
The Last Hotel
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $188 per night from Jun 9 to Jun 10
$188
per night
Jun 9 - Jun 10
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
The Last Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Ameristar Casino St. Charles
The price is $178 per night from Jun 30 to Jul 1
$178
per night
Jun 30 - Jul 1
Book a stay at this historic hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
St. Louis Union Station Hotel, Curio Collection by Hilton
River City Casino & Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 45 min drive from Ameristar Casino St. Charles
The price is $99 per night from Jul 2 to Jul 3
$99
per night
Jul 2 - Jul 3
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the restaurant and the helpful staff ...
River City Casino & Hotel
Angad Arts Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 31 min drive from Ameristar Casino St. Charles
The price is $149 per night from Jun 11 to Jun 12
$149
per night
Jun 11 - Jun 12
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the restaurant ...
Angad Arts Hotel
Hilton St. Louis at the Ballpark
4 out of 5
Fully refundableReserve now, pay when you stay
  • 36 min drive from Ameristar Casino St. Charles
The price is $161 per night from Jul 1 to Jul 2
$161
per night
Jul 1 - Jul 2
Book a stay at this business-friendly hotel in St. Louis. Enjoy 3 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the helpful staff and ...
Hilton St. Louis at the Ballpark
Marriott St. Louis Grand
4 out of 5
Fully refundableReserve now, pay when you stay
  • 35 min drive from Ameristar Casino St. Charles
The price is $151 per night from Jun 14 to Jun 15
$151
per night
Jun 14 - Jun 15
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Marriott St. Louis Grand
Don't see what you're looking for?
See all available properties in St. Charles
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in St. Charles

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in St. Charles for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in St. Charles as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag St. Charles 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in St. Charles starting at $99 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded St. Charles 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.