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21C Museum Hotel St Louis

4.5 star property

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Photo gallery for 21C Museum Hotel St Louis

Classic architecture with a grand entrance and evenly spaced windows.
Relax by the pool surrounded by a comfortable seating area and natural light.
Enjoy a luxurious bar experience with a curved countertop, comfortable seating, and a vibrant mural.
Experience the grandeur of our multi-level atrium, featuring a basketball court and balcony with a railing.
Relax in a classic room with a large pool table, elegant curtains, and a chandelier.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar
$183
includes taxes & fees
Aug 31 - Sep 1

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • Enterprise Center
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Cozy retreat with a bunk bed, round table, and vibrant artwork.

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Relax in a stylish space with a comfortable bed, armchair, and desk, surrounded by natural light and decorative touches.

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(67 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

Two spacious beds with white linens and multiple pillows, a modern headboard, and a stylish table with a lamp and flowers.

Deluxe Double Room, 2 Queen Beds

8.6 out of 10
Excellent
(19 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Relax in a stylish room with a tufted headboard, green sofa, and brown armchair.

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(23 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Cozy retreat with a neatly made bed, bedside table, and potted plant.

Suite, 1 King Bed

  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

Cozy retreat with a neatly made bed, bedside table, and potted plant.

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Two spacious beds with white linens and multiple pillows, a modern headboard, and a stylish table with a lamp and flowers.

Luxury Double Room, 2 Queen Beds

9.0 out of 10
Wonderful
(20 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

Similar properties

Relax in the elegant lobby, featuring a comfortable seating area with a sofa and armchairs, a staircase, and a chandelier.

Hyatt Regency St. Louis at The Arch

  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.2 out of 5, Very Good, (3935)
$195 nightly
The price is $195 total
includes taxes & fees
Hyatt Regency St. Louis at The Arch

About this property

21C Museum Hotel St Louis

4.5-star hotel in Downtown West
This smoke-free hotel features an indoor pool, a restaurant, and a fitness center. WiFi in public areas is free. Additionally, a bar/lounge, a steam room, and a coffee shop/cafe are onsite. Change of towels is available on request.
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
In addition to an indoor pool, 21C Museum Hotel St Louis provides a steam room and a fitness center. Dining options at the hotel include a restaurant and a coffee shop/cafe. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary wireless Internet access.

Business-related amenities at this 4.5-star property consist of a business center and meeting rooms. This luxury hotel also offers spa services, a vending machine, and concierge services. Parking is available onsite for a surcharge.

21C Museum Hotel St Louis is a smoke-free property.

Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Languages

English

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 933 out of 1292 reviews
Rating 8 - Good. 192 out of 1292 reviews
Rating 6 - Okay. 76 out of 1292 reviews
Rating 4 - Poor. 41 out of 1292 reviews
Rating 2 - Terrible. 50 out of 1292 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

michelle

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Great place and cool decor.

Service was great and the hotel/museum is beautiful.
Stayed 1 night in May 2025

10/10 Excellent

Erin

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in May 2025

8/10 Good

Lynn, St. Louis

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This is a very unique and interesting hotel. The art is beautiful as is the whole hotel. We had a corner king and it was plenty of room for 2. The furnishings were artsy and fun. Only complaint was that the pillows weee way too dense and BIG. Not very comfortable for our liking. The bed and sheets were lovely. Other than that we loved our stay. Thank you.
Stayed 1 night in May 2025

10/10 Excellent

Derek

Stayed 1 night in Apr 2025

10/10 Excellent

Margaret

Stayed 1 night in Apr 2025

10/10 Excellent

John

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great gym and pool, fun atmosphere on main level
Stayed 1 night in Apr 2025

8/10 Good

Jerome

Traveled with group
Liked: Cleanliness, property conditions & facilities, room comfort
Stayed 1 night in May 2025

4/10 Poor

John

Traveled with family and small children
Disliked: Staff & service, amenities, property conditions & facilities
I've stayed at 21c in Nashville and fully enjoyed the experience. In St. Louis it's not in a great neighborhood, very run down. The room phone never worked thank got for cell phones and elevators. The temperature controls didn't work properly. Fire alarm went off in the middle of the day while my 3 year old grandson was sleeping my daughter in law had to carry him down ten flights of stairs only to be told it was a mistake alarm. Valet parking is $50 for an open fenced lot across the street??? We walked around one afternoon and never really found anything cool or fun to go do... I would avoid this hotel get something g. Lose to the. Cardinals ball park same pricing with a way better experience!
Stayed 3 nights in Apr 2025

6/10 Okay

Jessica

Traveled with partner
Liked: Cleanliness, amenities
Disliked: Staff & service
Looks good and the toiletries brand is amazing
Stayed 1 night in Apr 2025

10/10 Excellent

Richard, Hickory

Stayed 1 night in Apr 2025

10/10 Excellent

Moe

Stayed 3 nights in Apr 2025

10/10 Excellent

Joni

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Spectacular restaurant, comfortable room, good museum, and it feels safe. The elevator has keyed access to each floor.
Stayed 2 nights in Apr 2025

8/10 Good

Fran

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Repeat Customer

This was our 2nd stay which speaks volumes! We love this place. It is upscale but relaxed. Historic but modern. Great location in walking distance of many attractions, but quiet. Clean. So Clean. I feel very comfortable walking around the room without shoes. Just a couple issues I will note...no after hours room service or even vending to get a snack or drink. And, only 1 roll of toilet paper. I think 2 rolls would have made us less nervous.😉
Stayed 1 night in Apr 2025

6/10 Okay

Siegfried

Liked: Cleanliness, amenities, property conditions & facilities
Bar service was very slow. Staff didn’t tell us there was a coffee shop.
Stayed 2 nights in Apr 2025

8/10 Good

Heather

Liked: Cleanliness, property conditions & facilities
This hotel has a lot of potential. It’s in a good area of the city. The hotel itself is so fun bright colored wallpaper art all over the place pool hot tub saunas pool tables literally has something for everybody. The front desk staff was OK. The valet attendant were fantastic all in all enjoyed the trip
Stayed 2 nights in Apr 2025

10/10 Excellent

Elia

Liked: Cleanliness, staff & service, property conditions & facilities
Me gusto mucho la atencion al cliente y el progecionalizmo. Gracias
Stayed 2 nights in Apr 2025

10/10 Excellent

Sandra

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We enjoyed our two nights at this hotel. The property was nice and we were able to walk to Enterprise stadium easily.
Stayed 2 nights in Apr 2025

10/10 Excellent

Hilary

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Loved everything! Will be back!

We will be coming back! We absolutely loved the hotel. From the rooms (we had a Deluxe King Suite) to the restaurants to the huge art museum…it did not disappoint. It was also within walking distance to our event at Enterprise Center. Staff were very friendly. Although we didn’t get in, the pool and hot tub both were large and looked nice. They also have two huge weight/workout rooms, treatment rooms, steam rooms, etc.
Stayed 1 night in Apr 2025

8/10 Good

Kenda

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Apr 2025

10/10 Excellent

Andrea, Du Quoin Illinois

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I stayed at this hotel for the stl go marathon and absolutely loved it! Super close to the start/finish so that was convenient. The hotel itself was beautiful and unique. From the art, to the amenities, and staff! Ugh it was all perfect. I will be staying here again next time I’m in town. 10/10!
One of the art galleries
View from the hotel window
Stayed 1 night in Apr 2025

10/10 Excellent

Samuel

Liked: Cleanliness, staff & service, property conditions & facilities
It’s easy to walk to most every venue I go to downtown. The hotel is amazingly beautiful.
Stayed 1 night in Apr 2025

2/10 Terrible

Steve

Disliked: Cleanliness, staff & service, property conditions & facilities, room comfort
We checked in the rain, not realizing they didn’t have a car port area or porters with umbrellas. Signage was very confusing outside and inside. The 1st room we were given had no electricity. The second room we were given had stains on the walls, carpet and bedding-which we suspected was mold. There was also someone’s medical patch on the shower floor. When my wife went to look at it closer, the shower floor had disgusting build up of something along the sides. My wife felt sick and we had already gotten ready for bed so when we called about the bed they said house cleaning was gone and we could move to another room by coming back downstairs and going through the same 30 minute process we had already done. Yes we should have checked the room before doing anything, but we’ve never had a boutique hotel that wasn’t more than acceptable. My wife slept in the chair, I slept in my clothes on top of other clothes on top of the bedding. The elevator appeared to have wine thrown all over it when we checked in, but was cleaned in the morning. They did refund the additional two nights we were scheduled to stay in, so I’m thankful for that. But we were told the one night “stay” would also be refunded which didn’t happen. This was one of the worst experiences I’ve had in my significant travel history.
Stayed 2 nights in Apr 2025

8/10 Good

Emma

Liked: Cleanliness, staff & service, property conditions & facilities
Great place in St. Louis.
Stayed 1 night in Apr 2025

10/10 Excellent

Kenneth

Liked: Cleanliness, staff & service, property conditions & facilities
No parking except valet
Stayed 1 night in Apr 2025

10/10 Excellent

Eric

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was a really nice place to stay. Me and my wife enjoyed the hotel, pool, dinning, and the staff. We are going to go back. hopfuly for my birthday. Thank you hotel 21c!
Stayed 2 nights in Apr 2025