Hotels Near
Medical Center District

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Featured Medical Center District Hotels

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundable
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
6.8/10 (1,384 reviews)
"The place has a nice breakfast they need to change towels they are old"

Reviewed on Apr 29, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8.4/10 Very Good! (2,955 reviews)
"It was centralized"

Reviewed on Apr 27, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean rooms in ...
8.4/10 Very Good! (1,001 reviews)
"Always a great stay with great customer service and very clean. The exterior will need a new coat of paint. The bed was very comfortable."

Reviewed on Apr 22, 2024

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the restaurant and the bar in our reviews. ...
8/10 Very Good! (3,525 reviews)
"Property was perfect for our trip. Aesthetic main lobby. Fun large games for down time. Great location for walking to Riverwalk and San Fernando. Staff was friendly."

Reviewed on Apr 30, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool in our ...
7.4/10 Good! (2,611 reviews)
"The price for parking"

Reviewed on Apr 29, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (2,792 reviews)
"Historic and cultural"

Reviewed on Apr 28, 2024

Menger Hotel
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.6/10 Good! (2,537 reviews)
"Good location close to shopping stores and restaurants. Friendly staff."

Reviewed on Apr 27, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking, and a 24-hour front desk. Our guests praise the pool and the restaurant in our reviews. ...
8.6/10 Excellent! (1,656 reviews)
"One of our favorites"

Reviewed on Apr 28, 2024

Crockett Hotel
Drury Plaza Hotel San Antonio Airport
Drury Plaza Hotel San Antonio Airport
3 out of 5
95 NE Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
9.2/10 Wonderful! (1,543 reviews)
"Excellent service, excellent breakfast, excellent rooms"

Reviewed on May 1, 2024

Drury Plaza Hotel San Antonio Airport
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (2,760 reviews)
"Love everything about this location!"

Reviewed on Apr 28, 2024

Hotel Gibbs Downtown Riverwalk
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy an outdoor pool, a full-service spa, and a rooftop terrace. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (2,730 reviews)
"Beautiful hotel beautiful people"

Reviewed on Apr 27, 2024

Hotel Contessa
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,613 reviews)
"Went for San Antonio fiesta and this location was perfectly located between Market Square and the Riverwalk. Will stay here again!"

Reviewed on Apr 29, 2024

Drury Plaza Hotel San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $62
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.