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5 Star Hotels in St. Charles

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Featured 5 Star St. Charles Hotels

Four Seasons Hotel St Louis
5 out of 5
Fully refundableReserve now, pay when you stay
  • 35 min drive from Ameristar Casino St. Charles
The price is $465 per night from Jun 9 to Jun 10
$465
per night
Jun 9 - Jun 10
Stay at this 5-star luxury hotel in St. Louis. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Popular attractions Gateway Arch and Busch Stadium ...
Four Seasons Hotel St Louis
The Ritz-Carlton, St. Louis
5 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from Ameristar Casino St. Charles
The price is $489 per night from Jun 30 to Jul 1
$489
per night
Jun 30 - Jul 1
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the room service ...
The Ritz-Carlton, St. Louis
Exquisitely Designed Townhome - JZ Vacation Rentals
5 out of 5
  • 34 min drive from Ameristar Casino St. Charles
The price is $169 per night from Jun 10 to Jun 11
$169
per night
Jun 10 - Jun 11
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and a casino. Popular attractions St. Louis Union Station and Enterprise ...
Exquisitely Designed Townhome - JZ Vacation Rentals
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Charming Studio in CWE - JZ Vacation Rentals
5 out of 5
  • 28 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury apartment in St. Louis. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions St. Louis Zoo and St. Louis Union ...
Charming Studio in CWE - JZ Vacation Rentals
Luxurious Townhome Next to Botanical Gardens - JZ Vacation Rentals
5 out of 5
  • 33 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury apartment in St. Louis. Enjoy free WiFi, free parking, and in-room washers/dryers. Popular attractions St. Louis Zoo and St. Louis ...
Luxurious Townhome Next to Botanical Gardens - JZ Vacation Rentals
Designer Home in Shaw Left Side - JZ Vacation Rentals
5 out of 5
  • 33 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and balconies. Popular attractions St. Louis Zoo and St. Louis Union Station ...
Designer Home in Shaw Left Side - JZ Vacation Rentals
Historic Townhome in Central West End - JZ Vacation Rentals
5 out of 5
  • 28 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions St. Louis Zoo and St. Louis ...
Historic Townhome in Central West End - JZ Vacation Rentals
Large & Luxurious 5bdrm 3Ba - JZ Vacation Rentals
5 out of 5
  • 26 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and in-room washers/dryers. Popular attractions St. Louis Zoo and St. Louis ...
Large & Luxurious 5bdrm 3Ba - JZ Vacation Rentals
Opulent 5-bedroom Soulard Home - JZ Vacation Rentals
5 out of 5
  • 38 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Busch Stadium and Enterprise ...
Opulent 5-bedroom Soulard Home - JZ Vacation Rentals
Stunning 4 Bedroom Home Near Tilles Park - JZ Vacation Rentals
5 out of 5
  • 34 min drive from Ameristar Casino St. Charles
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and patios. Popular attractions St. Louis Zoo and St. Louis Union Station ...
Stunning 4 Bedroom Home Near Tilles Park - JZ Vacation Rentals
Beautiful 3 Bedroom Home in The Grove - JZ Vacation Rentals
5 out of 5
  • 31 min drive from Ameristar Casino St. Charles
The price is $435 per night from Jun 22 to Jun 23
$435
per night
Jun 22 - Jun 23
Stay at this 5-star luxury vacation home in St. Louis. Enjoy free WiFi, free parking, and balconies. Popular attractions St. Louis Zoo and St. Louis Union Station ...
Beautiful 3 Bedroom Home in The Grove - JZ Vacation Rentals
Stylish Home Near Wine Country - JZ Vacation Rentals
5 out of 5
  • 1 hour drive from Ameristar Casino St. Charles
The price is $274 per night from Jun 16 to Jun 17
$274
per night
Jun 16 - Jun 17
Stay at this 5-star luxury vacation home in Washington. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Blumenhof Vineyards and Fort ...
Stylish Home Near Wine Country - JZ Vacation Rentals
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in St. Charles

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in St. Charles.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in St. Charles for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $169.

  • Amenities: St. Charles skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in St. Charles—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on St. Charles your way.