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5 Star Hotels in Panama City

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Featured 5 Star Panama City Hotels

Hotel Riu Plaza Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from Albrook Shopping Mall
The price is $106 per night from Jun 16 to Jun 17
$106
per night
Jun 16 - Jun 17
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 3 restaurants, and 24-hour room service. Our guests praise the breakfast and the pool in our ...
Hotel Riu Plaza Panama
JW Marriott Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from Albrook Shopping Mall
The price is $231 per night from Jun 15 to Jun 16
$231
per night
Jun 15 - Jun 16
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
JW Marriott Panama
Waldorf Astoria Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from Albrook Shopping Mall
The price is $183 per night from Jun 8 to Jun 9
$183
per night
Jun 8 - Jun 9
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Panama
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W Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from Albrook Shopping Mall
The price is $195 per night from Jun 16 to Jun 17
$195
per night
Jun 16 - Jun 17
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 spa tubs, and 2 bars/lounges. Our guests praise the breakfast and the pool in our reviews. ...
W Panama
Hilton Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from Albrook Shopping Mall
The price is $188 per night from Jul 2 to Jul 3
$188
per night
Jul 2 - Jul 3
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the pool and the helpful ...
Hilton Panama
Sofitel Legend Casco Viejo, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from Albrook Shopping Mall
The price is $292 per night from Jun 6 to Jun 7
$292
per night
Jun 6 - Jun 7
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our ...
Sofitel Legend Casco Viejo, Panama City
The Westin Playa Bonita Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min drive from Albrook Shopping Mall
The price is $169 per night from Jun 24 to Jun 25
$169
per night
Jun 24 - Jun 25
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
The Westin Playa Bonita Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 18 min drive from Albrook Shopping Mall
The price is $219 per night from Jun 7 to Jun 8
$219
per night
Jun 7 - Jun 8
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff ...
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Bristol Panama, a Registry Collection Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from Albrook Shopping Mall
The price is $180 per night from Jun 6 to Jun 7
$180
per night
Jun 6 - Jun 7
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the breakfast and the restaurant ...
Bristol Panama, a Registry Collection Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Panama City

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Panama City.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Panama City for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $106.

  • Amenities: Panama City skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Panama City—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Panama City your way.