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Hotels in Southwest Houston

Last Minute Hot Rate® Hotel Deals in Southwest Houston

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Choose from 1552 Southwest Houston Hotel Deals

Comfort Inn & Suites Southwest Fwy at Westpark
Comfort Inn & Suites Southwest Fwy at Westpark
2.5 out of 5
6687 Southwest Fwy, Houston, TX
  • 22 min walk from MD Anderson Cancer Center
The price is $53 per night from May 1 to May 2
$53
per night
May 1 - May 2
Stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
7/10 Good! (1,000 reviews)
Get what you pay for
"When we first arrived around 5pm ish, we were waiting on an open room due to no availability . We went back about an hour or so and were able to get a room. The elevator could use a bit updating, kind of nervous on it! The room was clean, and smelt fresh! It is a bit nosey but common in a busy hotel. ..."

Reviewed on Apr 22, 2024

Comfort Inn & Suites Southwest Fwy at Westpark
Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
  • 12 min walk from MD Anderson Cancer Center
The price is $170 per night from May 1 to May 2
$170
per night
May 1 - May 2
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (2,057 reviews)
"I liked it, but the fire alarm lights kept going off while we slept in bedroom..but everything else was fine"

Reviewed on Apr 21, 2024

Blossom Hotel Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $140 per night from May 24 to May 25
$140
per night
May 24 - May 25
Stay at this hotel in Houston. Enjoy free WiFi, breakfast, and a free area shuttle. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.4/10 Good! (1,018 reviews)
"Great stay for a long weekend. Enjoyed the welcome cookie and the shuttle service. Thank you!"

Reviewed on Apr 21, 2024

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
La Quinta Inn & Suites by Wyndham Houston Galleria Area
La Quinta Inn & Suites by Wyndham Houston Galleria Area
2.5 out of 5
1625 West Loop S, Houston, TX
  • 7 min drive from MD Anderson Cancer Center
The price is $76 per night from Apr 29 to Apr 30
$76
per night
Apr 29 - Apr 30
Stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in ...
7.6/10 Good! (1,160 reviews)
Not horrible, just needs updating.
"Room 202- Our shower didn’t work, was only able to use the tub. The carpet was nasty. Left our feet very dirty if we walked without shoes, needs to be replaced. Housekeeping portion was great tho."

Reviewed on Apr 24, 2024

La Quinta Inn & Suites by Wyndham Houston Galleria Area
Sonesta Essential Houston Westchase
Sonesta Essential Houston Westchase
3 out of 5
10850 Harwin Dr, Houston, TX
  • 4 min drive from MD Anderson Cancer Center
The price is $54 per night from Apr 28 to Apr 29
$54
per night
Apr 28 - Apr 29
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,001 reviews)
"No pool or spa as Advertised"

Reviewed on Apr 21, 2024

Sonesta Essential Houston Westchase
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
3.5 out of 5
6633 Travis St, Houston, TX
  • 4 min walk from MD Anderson Cancer Center
The price is $97 per night from May 11 to May 12
$97
per night
May 11 - May 12
Stay at this business-friendly hotel in Houston. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (1,004 reviews)
"Very close to what I needed in Houston."

Reviewed on Apr 20, 2024

Hilton Houston Plaza/Medical Center
Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston Galleria
3 out of 5
5190 Hidalgo St, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
The price is $118 per night from May 12 to May 13
$118
per night
May 12 - May 13
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
8.2/10 Very Good! (1,008 reviews)
"Nice stay good food check in/out very good"

Reviewed on Apr 22, 2024

Sonesta ES Suites Houston Galleria
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
  • 16 min walk from MD Anderson Cancer Center
The price is $126 per night from Apr 26 to Apr 27
$126
per night
Apr 26 - Apr 27
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (591 reviews)
"Not a lot of places to eat close by but overall would definitely stay again"

Reviewed on Apr 21, 2024

Hyatt Place Houston Medical Center
The Royal Sonesta Houston Galleria
The Royal Sonesta Houston Galleria
4 out of 5
2222 West Loop South, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $189 per night from May 24 to May 25
$189
per night
May 24 - May 25
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast, WiFi, and room service. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (1,011 reviews)
"Really nice. Clean. Amazing staff."

Reviewed on Apr 21, 2024

The Royal Sonesta Houston Galleria
The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by Hilton
4 out of 5
2400 West Loop S, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $169 per night from May 10 to May 11
$169
per night
May 10 - May 11
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast, WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,004 reviews)
"Great area"

Reviewed on Apr 20, 2024

The Chifley Houston, Tapestry Collection by Hilton
Hotel Derek
Hotel Derek
4 out of 5
2525 West Loop S, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $111 per night from May 12 to May 13
$111
per night
May 12 - May 13
Stay at this aparthotel in Houston. Enjoy free breakfast, free WiFi, and room service. Our guests praise the clean rooms in our reviews. Popular attractions ...
6.2/10 (2,077 reviews)
2 days in Houston
"Quick business trip. Hotel was clean and pleasant. Loved the retro mid-century style. Within walking distance to Galleria and may restaurants. In house restaurant/bar has a good happy hour."

Reviewed on Apr 18, 2024

Hotel Derek
InterContinental Houston, an IHG Hotel
InterContinental Houston, an IHG Hotel
4 out of 5
6750 Main St, Houston, TX
  • 2 min walk from MD Anderson Cancer Center
The price is $169 per night from May 11 to May 12
$169
per night
May 11 - May 12
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast, and room service. Our guests praise the restaurant and the helpful staff ...
9.2/10 Wonderful! (1,003 reviews)
Superb
"Had an amazing stay. The rooms were spacious, pristine, comfortable, and secure. The amenities such as luxury bath soap, slippers, and top notch service made our stay outstanding. Check in/out was simple and all staff were polite and courteous. Would absolutely stay here again and recommend this ..."

Reviewed on Apr 16, 2024

InterContinental Houston, an IHG Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Southwest Houston

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southwest Houston hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Houston.

Choosing the right hotel in Texas has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Houston’s 1,552 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $53. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southwest Houston hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Houston. No matter your reason for visiting Southwest Houston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Houston hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southwest Houston for as low as $53.

How many hotels are there in Southwest Houston?

With over 1,552 hotels in Southwest Houston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $53.

How to find cheap car rentals in Southwest Houston?

Finding a cheap car rental deal in Southwest Houston is as easy as scoring cheap hotels in Southwest Houston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Southwest Houston now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southwest Houston right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.