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Hotels in Southern Minnesota

Choose from 1108 Southern Minnesota Hotel Deals

Quality Inn near Medical Center
Quality Inn near Medical Center
2.5 out of 5
5708 Bandel Road NW, Rochester, MN
  • 12 min drive from Mayo Clinic
The price is $63 per night from May 6 to May 7
$63
per night
May 6 - May 7
Stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (469 reviews)
Good stay.
"My stay was just fine. The only thing I didn’t like was that there was no automated sliding front door. Kind of a pain in the butt."

Reviewed on Apr 25, 2024

Quality Inn near Medical Center
Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $149 per night from May 1 to May 2
$149
per night
May 1 - May 2
Stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 3 restaurants, and breakfast. Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (1,008 reviews)
"We love staying at the Kahler"

Reviewed on Apr 29, 2024

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $129 per night from May 1 to May 2
$129
per night
May 1 - May 2
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,190 reviews)
"It was overall good but our bed has springs poking out of the mattress. The restaurants breakfast was good but the lunch and dinner even with happy hour was overpriced."

Reviewed on Apr 28, 2024

Kahler Inn and Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $116 per night from May 7 to May 8
$116
per night
May 7 - May 8
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (559 reviews)
Excellent stay
"Great hotel. Very clean rooms, great staff. Would definitely recommend staying here."

Reviewed on Apr 28, 2024

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3.5 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $118 per night from May 11 to May 12
$118
per night
May 11 - May 12
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the ...
9/10 Wonderful! (527 reviews)
"We were there for a weeklong visit to the Mayo Clinic. Therefore, we wanted something with options to cook some of own meals. Hyatt House fulfilled this need. Although the refrigerator is a bit small, it served its purpose. Equipment for cooking was a bit under supplied, but we made do. All in all, ..."

Reviewed on Apr 24, 2024

Hyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $120 per night from May 19 to May 20
$120
per night
May 19 - May 20
Stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the restaurant and the helpful staff ...
8.8/10 Excellent! (525 reviews)
"Check in was easy and simple. The staff member was very friendly and helpful. They let us check in early, which was a bonus! The room was very clean! We were there for Dance Nationals so the access to the skywalk was perfect. A lot of food options around the area and we felt safe."

Reviewed on Apr 28, 2024

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $78 per night from May 19 to May 20
$78
per night
May 19 - May 20
Stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
7.8/10 Good! (266 reviews)
"Everything was amazing"

Reviewed on Apr 29, 2024

AmericInn by Wyndham Rochester Near Mayo Clinic
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $83 per night from May 5 to May 6
$83
per night
May 5 - May 6
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,004 reviews)
"Room was okay. But it seemed like a lot of shady people around. We didn’t feel safe."

Reviewed on Apr 26, 2024

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
The price is $123 per night from May 1 to May 2
$123
per night
May 1 - May 2
Stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. Popular ...
8/10 Very Good! (996 reviews)
"Lots of breakfast choices"

Reviewed on Apr 28, 2024

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $88 per night from May 24 to May 25
$88
per night
May 24 - May 25
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,003 reviews)
Overnight in Rochester
"The room was comfortable and quiet. I would definitely stay here again."

Reviewed on Apr 28, 2024

Hampton Inn Rochester-South
Aspen Select
Aspen Select
3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
The price is $112 per night from May 1 to May 2
$112
per night
May 1 - May 2
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (996 reviews)
"Staff was helpful and so friendly"

Reviewed on Apr 28, 2024

Aspen Select
AmericInn by Wyndham Mankato Event Center
AmericInn by Wyndham Mankato Event Center
2.5 out of 5
240 Stadium Road, Mankato, MN
  • 4 hours drive from Mayo Clinic
The price is $100 per night from May 19 to May 20
$100
per night
May 19 - May 20
Stay at this business-friendly hotel in Mankato. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,003 reviews)
"Great staff!"

Reviewed on Apr 28, 2024

AmericInn by Wyndham Mankato Event Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Southern Minnesota

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Minnesota.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Minnesota’s 1,108 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southern Minnesota hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Minnesota. No matter your reason for visiting Southern Minnesota, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southern Minnesota hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Minnesota for as low as $63.

How many hotels are there in Southern Minnesota?

With over 1,108 hotels in Southern Minnesota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.

How to find cheap car rentals in Southern Minnesota?

Finding a cheap car rental deal in Southern Minnesota is as easy as scoring cheap hotels in Southern Minnesota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Southern Minnesota now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southern Minnesota right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.