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Choose from 5744 Main Street Hyannis Hotel Deals

Americas Best Value Inn & Suites Hyannis Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
2 out of 5
206 Main St, Hyannis, MA
  • 6 min walk from John F. Kennedy Hyannis Museum
The price is $95 per night from Jun 9 to Jun 10
$95
per night
Jun 9 - Jun 10
Stay at this hotel in Hyannis. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the helpful staff in our reviews. Popular attractions ...
7.2/10 Good! (999 reviews)
"Definitely going back"

Reviewed on Jun 1, 2024

Americas Best Value Inn & Suites Hyannis Cape Cod
Cape Cod Inn
Cape Cod Inn
2 out of 5
447 Main St, Hyannis, MA
  • 3 min walk from John F. Kennedy Hyannis Museum
The price is $120 per night from Jun 16 to Jun 17
$120
per night
Jun 16 - Jun 17
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.6/10 Excellent! (335 reviews)
"We were allowed to check in early which was a great help because we were loaded down with suitcases and were exhausted from attending the Best Buddies Bicycle challenge."

Reviewed on Jun 6, 2024

Cape Cod Inn
Hyannis Inn
Hyannis Inn
2 out of 5
473 MAIN ST, Hyannis, MA
  • 4 min walk from John F. Kennedy Hyannis Museum
The price is $144 per night from Jun 13 to Jun 14
$144
per night
Jun 13 - Jun 14
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and a free beach shuttle. Our guests praise the pool and the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (822 reviews)
"This hotel is vintage Cape Cod in so many ways. How do you provide modern amenities with an old school Cape feel? This place does it quite well."

Reviewed on May 28, 2024

Hyannis Inn
Bayside Resort Hotel
Bayside Resort Hotel
3 out of 5
225 Route 28, West Yarmouth, MA
  • 26 min walk from John F. Kennedy Hyannis Museum
The price is $170 per night from Jun 9 to Jun 10
$170
per night
Jun 9 - Jun 10
Stay at this 3-star beach hotel in West Yarmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,035 reviews)
"Good view of bay"

Reviewed on Jun 3, 2024

Bayside Resort Hotel
Cape Sands Inn
Cape Sands Inn
2.5 out of 5
149 Main St - RT 28, West Yarmouth, MA
  • 23 min walk from John F. Kennedy Hyannis Museum
The price is $99 per night from Jun 16 to Jun 17
$99
per night
Jun 16 - Jun 17
Book a stay at this family-friendly motel in West Yarmouth. Enjoy free parking, an outdoor pool, and a sauna. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (957 reviews)
Would book again!!!
"The location was easily accessible, there were a ton of things to do at the property. Swimming pool and a hot tub. There was a Dunkin donuts down the road, and a couple of restaurants. I would recommend this location to anyone. And most importantly my wife felt safe."

Reviewed on Jun 6, 2024

Cape Sands Inn
Sea Crest Beach Resort
Sea Crest Beach Resort
3.5 out of 5
350 Quaker Rd, North Falmouth, MA
  • 42 min drive from John F. Kennedy Hyannis Museum
The price is $183 per night from Jun 9 to Jun 10
$183
per night
Jun 9 - Jun 10
Book a stay at this beach hotel in North Falmouth. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the restaurant in our reviews. ...
7.6/10 Good! (1,006 reviews)
"Need the room to be ready when checkin. I was waitting over an hour for checkin. But overal is good. Recomment stay there and will be there again."

Reviewed on May 30, 2024

Sea Crest Beach Resort
Chatham Bars Inn
Chatham Bars Inn
5 out of 5
297 Shore Rd, Chatham, MA
  • 38 min drive from John F. Kennedy Hyannis Museum
The price is $510 per night from Jun 9 to Jun 10
$510
per night
Jun 9 - Jun 10
Book a stay at this luxury resort in Chatham. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the property condition in our reviews. ...
9/10 Wonderful! (695 reviews)
"I really liked the high flow of water in the showers. Room was quiet and relaxing"

Reviewed on May 31, 2024

Chatham Bars Inn
Aiden by Best Western Cape Cod - West Yarmouth
Aiden by Best Western Cape Cod - West Yarmouth
3 out of 5
476 Route 28, West Yarmouth, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $143 per night from Jun 12 to Jun 13
$143
per night
Jun 12 - Jun 13
Stay at this 3-star business-friendly hotel in West Yarmouth. Enjoy free parking, an outdoor pool, and breakfast (surcharge). Our guests praise the restaurant ...
8/10 Very Good! (862 reviews)
"On a big road with stores and restaurants nearby. The staff were nice. The facilities were fine, and the breakfast was ok. I was missing a “do not disturb” sign but had both small large and small toiletries in the room."

Reviewed on May 29, 2024

Aiden by Best Western Cape Cod - West Yarmouth
The Villages at Ocean Edge
The Villages at Ocean Edge
3.5 out of 5
One Villages Drive, Brewster, MA
  • 31 min drive from John F. Kennedy Hyannis Museum
The price is $225 per night from Jun 9 to Jun 10
$225
per night
Jun 9 - Jun 10
Stay at this 3.5-star spa resort in Brewster. Enjoy 3 outdoor pools, a full-service spa, and 3 restaurants. Our guests praise the clean rooms in our reviews. ...
8/10 Very Good! (922 reviews)
"Very accommodating staff. Convenient shuttle. Enjoyed the option of 3 outdoor pools and 2 indoor pools."

Reviewed on May 29, 2024

The Villages at Ocean Edge
Hyannis Travel Inn
Hyannis Travel Inn
2.5 out of 5
18 North St, Hyannis, MA
  • 4 min walk from John F. Kennedy Hyannis Museum
The price is $130 per night from Jun 9 to Jun 10
$130
per night
Jun 9 - Jun 10
Stay at this hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
9.4/10 Exceptional! (1,018 reviews)
"Excellent"

Reviewed on Jun 6, 2024

Hyannis Travel Inn
Admiralty Inn & Suites - a Red Collection Hotel
Admiralty Inn & Suites - a Red Collection Hotel
2 out of 5
51 Teaticket Highway, East Falmouth, MA
  • 41 min drive from John F. Kennedy Hyannis Museum
The price is $141 per night from Jun 9 to Jun 10
$141
per night
Jun 9 - Jun 10
Book a stay at this business-friendly motel in East Falmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (19 reviews)
"Room was very clean."

Reviewed on Jun 3, 2024

Admiralty Inn & Suites - a Red Collection Hotel
Cape Codder Resort and Spa
Cape Codder Resort and Spa
3 out of 5
1225 Iyannough Rd, Hyannis, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $175 per night from Jun 16 to Jun 17
$175
per night
Jun 16 - Jun 17
Book a stay at this spa resort in Hyannis. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the clean rooms in ...
7.4/10 Good! (1,004 reviews)
Patience for renovation, but still quite nice
"Other than still being under renovation, it was quite nice. Often hotels that allow dogs are not so nice, and this was. In August the renovations will be complete, and will likely be even better."

Reviewed on Jun 3, 2024

Cape Codder Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Main Street Hyannis

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Main Street Hyannis.

Choosing the right hotel in Massachusetts has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Main Street Hyannis’s 5,744 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $95. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Main Street Hyannis hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Main Street Hyannis. No matter your reason for visiting Main Street Hyannis, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Main Street Hyannis hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Main Street Hyannis for as low as $95.

How many hotels are there in Main Street Hyannis?

With over 5,744 hotels in Main Street Hyannis, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $95.

How to find cheap car rentals in Main Street Hyannis?

Finding a cheap car rental deal in Main Street Hyannis is as easy as scoring cheap hotels in Main Street Hyannis. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Main Street Hyannis now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Main Street Hyannis right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.