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Hotels in East Prairie

Choose from 29 East Prairie Hotel Deals

Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $67 per night from May 14 to May 15
$67
per night
May 14 - May 15
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
7.4/10 Good! (31 reviews)
Adequate for the price
"Considering the price of the room, it was adequate. Thankfully it was a cooler weekend (the previous week had been uncharacteristically warm) or we would have had to move rooms due to an inadequate air conditioning unit. That being said, it was a clean room and the bed was comfortable. The motel ..."

Reviewed on Apr 22, 2024

Country Yard Inn and Suite
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $99 per night from May 19 to May 20
$99
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,002 reviews)
"Easy access of the highway in a very safe and convenient location. Newer hotel and staff was excellent. The included dinner and breakfast was an unexpected surprise and didn’t disappoint."

Reviewed on May 9, 2024

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $71 per night from May 27 to May 28
$71
per night
May 27 - May 28
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
Great staff, poor conditions
"The staff was very friendly but once we got to the room, there was blood on the top sheet and hair in the shower. We were only there for a quick sleep on a long road trip so I didn’t bother telling anyone. Just pulled off the comforter and slept on the sheets."

Reviewed on May 7, 2024

Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $94 per night from May 19 to May 20
$94
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (1,002 reviews)
"So glad I found the Pear Tree Inn. Clean room and a comfortable bed and the staff were wonderful!"

Reviewed on May 8, 2024

Pear Tree Inn Sikeston
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $101 per night from May 19 to May 20
$101
per night
May 19 - May 20
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"It was hard to find. No prominant sign. Otherwise ok."

Reviewed on May 8, 2024

Best Western Plus Sikeston
Travel Inn & Suites
Travel Inn & Suites
2.5 out of 5
100 Matthews Lane, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $73 per night from May 14 to May 15
$73
per night
May 14 - May 15
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (521 reviews)
"Rooms a little small."

Reviewed on May 9, 2024

Travel Inn & Suites
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $123 per night from May 19 to May 20
$123
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (340 reviews)
"Went for the eclipse and paid an outrageous price but otherwise a very nice hotel"

Reviewed on Apr 16, 2024

Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $123 per night from May 19 to May 20
$123
per night
May 19 - May 20
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (264 reviews)
"Great place and very clean and friendly staff!"

Reviewed on May 5, 2024

Hampton Inn Sikeston
Red Roof Inn Sikeston - Marston
Red Roof Inn Sikeston - Marston
2 out of 5
501 SE Outer Rd, Marston, MO
  • 8 hours drive from Mississippi River
The price is $75 per night from May 14 to May 15
$75
per night
May 14 - May 15
Stay at this motel in Marston. Enjoy free breakfast, free WiFi, and free parking.
7.2/10 Good! (72 reviews)
"Nice clean hotel. Will stay here again"

Reviewed on May 2, 2024

Red Roof Inn Sikeston - Marston
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 7 hours drive from Mississippi River
The price is $92 per night from May 19 to May 20
$92
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the clean rooms in our reviews. ...
8.2/10 Very Good! (194 reviews)
The Best Comfort Inn !
"The best value for money I have ever had. Exceptional service and cleanliness. My room was fantastic. Huge and spotless. Theres an elevator and they are pet friendly. I travel a great deal and this was the best. Good breakfast with lots of choices, including healthy choices. Safe area right next ..."

Reviewed on May 5, 2024

Comfort Inn & Suites Sikeston I-55
Super 8 by Wyndham Charleston MO
Super 8 by Wyndham Charleston MO
2 out of 5
310 S Story St, Charleston, MO
  • 7 hours drive from Mississippi River
The price is $68 per night from May 14 to May 15
$68
per night
May 14 - May 15
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking.
6.6/10 (493 reviews)
"Overall a clean good place to spend the night, a little on the older side but maintained and had friendly staff."

Reviewed on Apr 25, 2024

Super 8 by Wyndham Charleston MO
Quality Inn Charleston I-57
Quality Inn Charleston I-57
2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
  • 7 hours drive from Mississippi River
The price is $68 per night from Jun 3 to Jun 4
$68
per night
Jun 3 - Jun 4
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.8/10 (325 reviews)
"no food"

Reviewed on Feb 25, 2024

Quality Inn Charleston I-57
See all 29 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in East Prairie

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in East Prairie.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of East Prairie’s 29 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% East Prairie hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in East Prairie. No matter your reason for visiting East Prairie, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About East Prairie hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in East Prairie for as low as $67.

How many hotels are there in East Prairie?

With over 29 hotels in East Prairie, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in East Prairie?

Finding a cheap car rental deal in East Prairie is as easy as scoring cheap hotels in East Prairie. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to East Prairie now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to East Prairie right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.