Search Cheap Flights to
Santa Cruz from

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Flights to Santa Cruz starting at

Have you been telling yourself, “2025 is the year I travel more and sit less”? Well, here we are and there you are. So, where are you going? Looks like a flight to Santa Cruz is calling. Good thing we can help you bag that flight out of town for cheap, so you can get your resolutions resolved.

Travel like you mean it

When you land it’s not straight to the tourist traps for you. You have things to do and see in Santa Cruz that aren’t on a map or in the “Best of. . .” guides. You know this region is filled with hidden haunts, locals-only know favorites, and the off-beat-so-weird-it’s-amazing places. And you plan to find every last one of them. Good thing you’ll save a grip of cash on your flight so you can daytrip far and wide.

You won’t have to wing it

So how do you score that killer deal on a flight to Santa Cruz? Easy, go through us. These aren’t pie in the sky deals, but ones you can actually score. Filter flights to Santa Cruz by:

  • Hotwire Hot Rate: Do you have a flexible schedule? Hit up the Hotwire Hot Rate and land a super cheap flight to Santa Cruz. We’ll reveal the airline and exact time after you book.
  • Price: How low can we go? Find out. We have prices from to .
  • Duration: Want to get to Santa Cruz as fast as you can? Or maybe you don’t mind taking your time to save a few bucks here and there.
  • Departure or Arrival: Like to arrive in the a.m. to get your day going? Or are you a night owl that knows the best fun happens late night? The choice is yours.

So are you going to live up to those travel plans or kick the can to next year? Book your flight to Santa Cruz today and get going.

Last Minute Hotel Deals in Santa Cruz

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
The price is $111 per night from Apr 25 to Apr 26
$111
includes taxes & fees
Apr 25 - Apr 26
Stay at this 5-star luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
9/10 Wonderful! (187 reviews)
"Everything was amazing! Great staff and amazing service!"

Reviewed on Mar 25, 2025

Marriott Santa Cruz de la Sierra Hotel
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
The price is $127 per night from Apr 5 to Apr 6
$127
includes taxes & fees
Apr 5 - Apr 6
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (379 reviews)
"Superb Hotel. Lovely staff Pool area great. Close to everything in a good area."

Reviewed on Mar 14, 2025

Camino Real Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is $127 per night from Apr 24 to Apr 25
$127
includes taxes & fees
Apr 24 - Apr 25
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (312 reviews)
"Amazing"

Reviewed on Mar 30, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Save an average of 15% on thousands of hotels when you're signed in
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13, Aeropuerto Internacional Viru Viru, Santa Cruz, Santa Cruz
The price is $108 per night from Apr 5 to Apr 6
$108
includes taxes & fees
Apr 5 - Apr 6
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (285 reviews)
"Super easy check in, most of the details are handled by Expedia. It’s a great place to relax before an early morning flight out of VVI. Clean, comfortable and everything you need."

Reviewed on Mar 1, 2025

Sun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.