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Hotels in Cape Girardeau

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Check Last Minute Cape Girardeau Hotel Deals

Tonight May 3 - May 4This weekend May 3 - May 5

Choose from 157 Cape Girardeau Hotel Deals

Quality Inn
Quality Inn
2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
  • 9 min drive from Southeast Missouri State University
The price is $64 per night from May 5 to May 6
$64
per night
May 5 - May 6
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
6.8/10 (454 reviews)
"Nice room, nice breakfast area."

Reviewed on Apr 24, 2024

Quality Inn
Auburn Place Hotel And Suites
Auburn Place Hotel And Suites
2.5 out of 5
3265 William St, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
The price is $79 per night from May 23 to May 24
$79
per night
May 23 - May 24
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"No issues for an older hotel. Good breakfast. Very friendly staff. Clean room."

Reviewed on Apr 30, 2024

Auburn Place Hotel And Suites
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
The price is $67 per night from Jun 2 to Jun 3
$67
per night
Jun 2 - Jun 3
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,000 reviews)
"Everything was as expected."

Reviewed on Apr 29, 2024

Pear Tree Inn Cape Girardeau West
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
The price is $117 per night from May 12 to May 13
$117
per night
May 12 - May 13
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.6/10 Exceptional! (1,001 reviews)
"Very friendly staff with very clean and nice rooms"

Reviewed on Apr 27, 2024

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
The price is $108 per night from May 8 to May 9
$108
per night
May 8 - May 9
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (771 reviews)
"Stay was very relaxing"

Reviewed on May 2, 2024

Drury Inn & Suites Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
The price is $117 per night from May 9 to May 10
$117
per night
May 9 - May 10
Stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,001 reviews)
"Staff very friendly and helpful !"

Reviewed on Apr 29, 2024

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
The price is $67 per night from May 8 to May 9
$67
per night
May 8 - May 9
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
"Check is was extremely smooth. Room is great. Got to check in early. Christina ar the chech in desk was very helpful with our request."

Reviewed on Apr 28, 2024

Pear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau, an IHG Hotel
Candlewood Suites Cape Girardeau, an IHG Hotel
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
The price is $84 per night from May 6 to May 7
$84
per night
May 6 - May 7
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the clean rooms in our reviews. ...
8/10 Very Good! (617 reviews)
"VERY CLEAN HOTEL AND NICE STAFF ENCOUNTERED."

Reviewed on Apr 29, 2024

Candlewood Suites Cape Girardeau, an IHG Hotel
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3 out of 5
400 Broadway St., Cape Girardeau, MO
  • 14 min walk from Southeast Missouri State University
The price is $130 per night from May 12 to May 13
$130
per night
May 12 - May 13
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (337 reviews)
"A clean facility"

Reviewed on Apr 23, 2024

Courtyard by Marriott Cape Girardeau Downtown
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
2.5 out of 5
207 S Mt Auburn Rd, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
The price is $114 per night from May 19 to May 20
$114
per night
May 19 - May 20
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (617 reviews)
"Staff at Hampton Inn fixed Expedias attempts to cancel our reservation. Took over an hour of repeated calls and being hung up on by Expedia. YAY Hampton Inn. Without you, we would slept in our rental car as all hotels in town were booked due to the eclipse. BOO Expedia - we’ll never book with you ..."

Reviewed on Apr 29, 2024

Hampton Inn Cape Girardeau I 55 East
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 out of 5
433 CAPE WEST CROSSINGS, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
The price is $105 per night from May 12 to May 13
$105
per night
May 12 - May 13
Stay at this hotel in Cape Girardeau. Enjoy breakfast, WiFi, and onsite parking. Popular attractions Fort D Historic Site and Cape Splash Family Aquatic Center ...
7.4/10 Good! (10 reviews)
New Hotel
"This is a new hotel, 2024, and is absolutely beautiful as far as hotels go. The layout works. The rooms are spacious and the bathrooms have tubs. This was a normal two bed room. There were a lot of guests present at the time, yet the hotel remained pleasantly quiet."

Reviewed on Apr 21, 2024

Fairfield Inn & Suites by Marriott Cape Girardeau
Town House Inn Cape Giradreau
Town House Inn Cape Giradreau
2.5 out of 5
505 North Kingshighway Street, Cape Girardeau, MO
  • 28 min walk from Southeast Missouri State University
The price is $73 per night from May 8 to May 9
$73
per night
May 8 - May 9
Stay at this motel in Cape Girardeau. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Cape Splash Family Aquatic Center and Show ...
6/10 (136 reviews)
"Nothing like the one in jackson. I stayed at the townhouse inn in jackson mo then the one in cape girardeau. The one in jackson 10 stars the one in cape 2 stars so its woryh the 5 min drive"

Reviewed on Jul 29, 2023

Town House Inn Cape Giradreau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Cape Girardeau

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Cape Girardeau hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Cape Girardeau.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Cape Girardeau’s 157 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Cape Girardeau hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Cape Girardeau. No matter your reason for visiting Cape Girardeau, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Cape Girardeau hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Cape Girardeau for as low as $64.

How many hotels are there in Cape Girardeau?

With over 157 hotels in Cape Girardeau, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.

How to find cheap car rentals in Cape Girardeau?

Finding a cheap car rental deal in Cape Girardeau is as easy as scoring cheap hotels in Cape Girardeau. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Cape Girardeau now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Cape Girardeau right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.