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Hotels in Santa Cruz

Choose from 190 Santa Cruz Hotel Deals

Delfines Collection Hotel By Mercure
Delfines Collection Hotel By Mercure
3.5 out of 5
Calle Pablo Sanz 29 Equipetrol, Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
The price is $39 per night from Apr 27 to Apr 28
$39
per night
Apr 27 - Apr 28
Stay at this 3.5-star hotel in Santa Cruz. Enjoy an outdoor pool. Popular attractions Ventura Mall and Santa Cruz Zoo are located nearby. Discover genuine guest ...
8.4/10 Very Good! (18 reviews)
"Buena ubicación. Personal amable. Lugar tranquilo. Habitaciones confortables."

Reviewed on Apr 14, 2024

Delfines Collection Hotel By Mercure
Marriott Santa Cruz de la Sierra Hotel
Marriott Santa Cruz de la Sierra Hotel
5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
The price is $118 per night from Apr 27 to Apr 28
$118
per night
Apr 27 - Apr 28
Stay at this 5-star luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the property condition in our ...
8.8/10 Excellent! (143 reviews)
"Clean comfortable room and beds. Nice fitness center. Small pool and hot tub could be hotter. Munimal vegan options at restaurant but lots of other places nearby."

Reviewed on Apr 17, 2024

Marriott Santa Cruz de la Sierra Hotel
TRYP by Wyndham Santa Cruz
TRYP by Wyndham Santa Cruz
4 out of 5
Av. San Martin, Calle 9 Este, no. 4, Equipetrol., Santa Cruz
  • 26 min walk from Plaza 24 de Septiembre
The price is $64 per night from Apr 29 to Apr 30
$64
per night
Apr 29 - Apr 30
Stay at this 4-star hotel in Santa Cruz. Enjoy free WiFi, breakfast, and a fitness center. Popular attractions Santa Cruz Zoo and Ventura Mall are located nearby. ...
9.2/10 Wonderful! (72 reviews)
"Highly recommend staying at the hotel"

Reviewed on Apr 2, 2024

TRYP by Wyndham Santa Cruz
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 out of 5
Ave. San Martin, #455, Santa Cruz
  • 28 min walk from Plaza 24 de Septiembre
The price is $122 per night from May 14 to May 15
$122
per night
May 14 - May 15
Stay at this spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (280 reviews)
Just ok rooms by pool
"Hotel is great. Service is better. Rooms by the pool, which should be the centerpiece of the property, are a bit dated. Bed was just ok. Comfortable enough but not great."

Reviewed on Apr 17, 2024

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Camino Real Hotel
Camino Real Hotel
4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
  • 5 min drive from Plaza 24 de Septiembre
The price is $128 per night from Apr 24 to Apr 25
$128
per night
Apr 24 - Apr 25
Stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, 2 bars/lounges, and a full-service spa. Popular attractions Ventura Mall and Santa Cruz Zoo are ...
8.6/10 Excellent! (327 reviews)
Excelente!!!
"Excelente hotel, muy confortable. Lo único malo es que no se puede desayunar con la ropa que saldrás al trabajo, hay mucho olor a comida en el restaurante y se queda en la ropa."

Reviewed on Apr 18, 2024

Camino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 out of 5
San Martin Avenue Esq Street E - E, Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
The price is $103 per night from Apr 26 to Apr 27
$103
per night
Apr 26 - Apr 27
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Santa Cruz Zoo are ...
9/10 Wonderful! (192 reviews)
"A 2 week stay for business. The room was excellent. The breakfast that comes included is top notch with multiple options."

Reviewed on Mar 17, 2024

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Sun Hotel
Sun Hotel
3.5 out of 5
Av. Banzer Km 13, Aeropuerto Internacional Viru Viru, Santa Cruz, Santa Cruz
  • 21 min drive from Plaza 24 de Septiembre
The price is $130 per night from Apr 27 to Apr 28
$130
per night
Apr 27 - Apr 28
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the helpful staff in ...
8.2/10 Very Good! (240 reviews)
"This was such a convenient place to stay one night before leaving the country. We were tired but got renewed by the pool, food, massage, and rest."

Reviewed on Apr 1, 2024

Sun Hotel
Hotel LP Equipetrol
Hotel LP Equipetrol
3.5 out of 5
Dr Victor Pinto, Equipetrol, esquina Marcelo Terceros Banzer, Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
The price is $59 per night from Apr 24 to Apr 25
$59
per night
Apr 24 - Apr 25
Stay at this 3.5-star hotel in Santa Cruz. Enjoy free WiFi, breakfast, and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located nearby. ...
8/10 Very Good! (182 reviews)
"Staff was very helpful, the room was tidy and well equipped. Minibar is priced well."

Reviewed on Apr 2, 2024

Hotel LP Equipetrol
Swissôtel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La Sierra
4.5 out of 5
Canal Isuto, Los Pachio, Barrio 2 De Abril, Santa Cruz
  • 6 min drive from Plaza 24 de Septiembre
The price is $115 per night from Apr 24 to Apr 25
$115
per night
Apr 24 - Apr 25
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free WiFi, 2 bars/lounges, and a full-service spa. Popular attractions Ventura Mall and Santa Cruz Zoo ...
8.8/10 Excellent! (40 reviews)
"Good"

Reviewed on Jul 19, 2023

Swissôtel Santa Cruz De La Sierra
Hotel LP Santa Cruz Centro
Hotel LP Santa Cruz Centro
3 out of 5
Av.Ejercito Nacional 290, (frente Stadium Tahuichi), Santa Cruz
  • 18 min walk from Plaza 24 de Septiembre
The price is $54 per night from Apr 27 to Apr 28
$54
per night
Apr 27 - Apr 28
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast. Popular attractions Ramon Tahuichi Aguilera Stadium ...
7.8/10 Good! (272 reviews)
"Best 👍"

Reviewed on Mar 14, 2024

Hotel LP Santa Cruz Centro
Hotel G
Hotel G
3.5 out of 5
Av. Pedro Ribera #750, Santa Cruz, Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
The price is $39 per night from May 22 to May 23
$39
per night
May 22 - May 23
Stay at this 3.5-star hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast. Popular attractions Las Brisas Shopping Center and Santa Cruz Zoo are ...
7.6/10 Good! (87 reviews)
"Everything was great. Only down side was the construction being infront of the hotel. But the location is good area."

Reviewed on Sep 15, 2023

Hotel G
Ibis Santa Cruz DE LA Sierra
Ibis Santa Cruz DE LA Sierra
3.5 out of 5
AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz
  • 16 min walk from Plaza 24 de Septiembre
The price is $62 per night from May 7 to May 8
$62
per night
May 7 - May 8
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast. Popular attractions Municipal Library and Arenal Park ...
9.6/10 Exceptional! (26 reviews)
Good hotel
"I had a great stay at this hotel. It has a good location, within reasonable walking distance to the old town or the restaurant area, though Uber is very easy and cheap. The hotel is good, modern and clean . The ambience is very quiet , I would have liked a more interesting and lively vibe. The room ..."

Reviewed on Mar 31, 2024

Ibis Santa Cruz DE LA Sierra
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Santa Cruz

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Cruz.

Choosing the right hotel in Santa Cruz has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Cruz’s 190 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $39. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Santa Cruz hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Cruz. No matter your reason for visiting Santa Cruz, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Cruz hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Cruz for as low as $39.

How many hotels are there in Santa Cruz?

With over 190 hotels in Santa Cruz, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $39.

How to find cheap car rentals in Santa Cruz?

Finding a cheap car rental deal in Santa Cruz is as easy as scoring cheap hotels in Santa Cruz. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Santa Cruz now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Santa Cruz right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.