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Panama Vacation Packages

Panama Flight + Hotel packages

Royal Decameron Panama Plus - All Inclusive
Royal Decameron Panama All Inclusive
Central Hotel Panama Casco Viejo
Riu Playa Blanca - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
Las Americas Golden Tower Panama
Amarla Boutique Hotel Casco Viejo - Adults Only
Hotel Casa Panamá
Prices and availability subject to change. Additional terms may apply.

3-4 Night Vacations in Panama

Royal Decameron Panama Plus - All Inclusive
Royal Decameron Panama All Inclusive
Central Hotel Panama Casco Viejo
Dreams Playa Bonita Panama - All Inclusive
Prices and availability subject to change. Additional terms may apply.

5-7 Night Vacations in Panama

Royal Decameron Panama Plus - All Inclusive
Royal Decameron Panama All Inclusive
Riu Playa Blanca - All Inclusive
Las Americas Golden Tower Panama
Prices and availability subject to change. Additional terms may apply.

Cheap Hotel Deals in Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 3 restaurants, and a fitness center. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in ...
Dreams Playa Bonita Panama - All Inclusive
Crowne Plaza Panama Airport, an IHG Hotel

Crowne Plaza Panama Airport, an IHG Hotel

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport, an IHG Hotel
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Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Megapolis Hotel Panamá
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Decapolis Hotel Panama City
Bijao Resort by Evenia - All Inclusive

Bijao Resort by Evenia - All Inclusive

3.5 out of 5
Carretera Interamericana km 108, Rio Hato
Stay at this 3.5-star beach hotel in Rio Hato. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
Bijao Resort by Evenia - All Inclusive
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the breakfast and the helpful staff in our ...
Las Americas Golden Tower Panama
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina, Panama City, Panama
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Principe Hotel and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

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United
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Find cheap hotels in Panama

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Panama hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Panama.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Panama’s 2,530 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $54. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Panama hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Panama. No matter your reason for visiting Panama, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Panama hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Panama for as low as $54.

How many hotels are there in Panama?

With over 2,530 hotels in Panama, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $54.

How to find cheap car rentals in Panama?

Finding a cheap car rental deal in Mexico and Central America is as easy as scoring cheap hotels in Panama. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Panama now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Panama right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.