Cheap Rental Car Deals in Panama

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Enjoy modest savings*

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Find Panama Car Rentals

Hotwire.com makes it easy for you to book your next Panama car rental. We work with the best car rental companies in Panama, bringing you discount car rental rates and a wide variety of car rental classes including economy, compact, midsize, full-size, convertible, van, luxury, full size and SUV rentals. Our partner car rental companies in Panama offer different pick-up and drop-off options. If you are ready to book your Panama car rental, follow the links on this page to view more information and details on your next car rental.


Hotwire offers a wide selection of rental cars in Panama to meet nearly every need. If you need any special equipment, like a child seat or ski rack, let us know and we will forward your request on to the rental car company. And what’s more, when you choose to rent a car from one of our Panama airport car rental partners you’ll be dealing with a rental car company that has made a special commitment to provide Hotwire customers with great customer service, a wide choice of top quality cars, and competitive total pricing.


Hotwire offers many Panama rental cars pick up locations

Find the best place to get your Panama airport rental cars by searching tons of pickup locations with Hotwire

*Savings are based on actual Hot Rate® car rentals made from airport pick-up locations as compared with the lowest published rates found on leading retail travel sites. Prices are dynamic and vary based on the booking date and length of the car rental. There is no guarantee these savings or rates will be in effect at the time of your search. Availability is limited. Hot Rate® cars are different from retail rates. With Hot Rate® cars you enter the location, date, and car class. The car rental company is revealed only after booking. All bookings are final.